Description

Paramètres techniques

Hexarelin2

Factory 2

musclepic 6

### 1. Overview

Hexarelin, first synthesized by Italian researchers, is a highly efficient and stable **GHRP agonist**. Structurally, it exhibits stronger receptor affinity and metabolic stability than traditional peptides such as GHRP-6 and GHRP-2, thus earning the title of "second-generation growth peptide."

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### 2. Chemical and Physical Properties

* **Molecular Weight**: 887.04 Da

* **CAS Number**: 140703-51-1

* **Appearance**: The pure product is mostly a **white to off-white lyophilized powder**, extremely fine, and easily hygroscopic.

* **Solubility**: Soluble in water, acetic acid, and some polar solvents; most stable at pH 5.0–7.0.

* **Storage Conditions:** Store at -20℃ in a freeze-dried state, avoiding light and humidity. In solution form, store at a low temperature and protected from light; do not exceed 7 days.

* **Purity:** High-quality research-grade products typically have a purity >=98% (HPLC detection).

The molecular structure of Hexarelin contains several aromatic amino acids (such as tryptophan and phenylalanine), which gives it a characteristic absorption peak (approximately 280 nm) under UV absorption spectroscopy, facilitating quality detection and purity analysis.

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### 3. Classification and Derivative Systems of Hexarelin

1. **Prototype Hexarelin (Standard Form)**

This is the basic molecular structure, commonly used in basic biomedical research or experimental animal models, primarily acting on the **GHS-R1a receptor** (growth hormone secretion receptor).

* Advantages: Stable structure, high activity, and strong reproducibility.

* Uses: Used for research on the mechanism of growth hormone secretion and pharmacological testing.

2. **Hexarelin Salt Derivatives**

These mainly include **acetate** and **lyophilized acetate powder**.

* Advantages: Better solubility and stability, suitable for preparing injection solutions or in vitro experiments.

* Appearance: White or slightly yellow powder with good flowability.

* Applications: Medical research, tissue regeneration research, and in vivo metabolic analysis.

3. **Hexarelin Analogs and Modified Peptides**

Researchers have created various variants through amino acid substitution or terminal modification, such as **Desmopressin-Hexa** and **Hexarelin-amide**.

* Advantages: Longer duration of action and extended half-life; some modified forms are more stable in lipid environments.

* Disadvantages: Higher synthesis cost; some derivatives are still in the experimental stage.

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### 4. Bioactivity and Mechanism of Action

The main physiological effect of hexarelin is achieved by activating the **growth hormone secretion receptor (GHS-R1a)**, similar to the pathway of the natural hormone **ghrelin**. The mechanisms are as follows:

1. **Stimulation of GH secretion:**

After hexarelin binds to GHS-R1a in the anterior pituitary gland, it promotes the release of GH follicles, thereby increasing serum GH concentration.

2. **Promotion of IGF-1 synthesis:**

The increase in GH further stimulates the liver to secrete insulin-like growth factor-1 (IGF-1), thereby promoting cell growth, muscle protein synthesis, and tissue repair.

3. **Cardiovascular protective effect:**

Studies have shown that hexarelin can protect cardiomyocytes by inhibiting myocardial fibrosis and reducing oxidative stress and apoptosis.

4. **Regulation of lipid metabolism:**

Long-term effects can improve lipid metabolism and enhance basal metabolic rate, potentially providing adjunctive benefits for obesity or metabolic syndrome.

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### 5. Advantages and Characteristics

1. **Higher receptor affinity and GH-stimulating efficacy**;

2. **Good tolerability**, with minimal risk of desensitization with prolonged use;

3. **Strong structural stability**, with a long half-life in body fluids (approximately 1 hour);

4. **High safety profile**, with no significant abnormal increase in cortisol or prolactin;

5. **Outstanding muscle synthesis and repair capabilities**, used in tissue regeneration research;

6. **Unique cardiovascular protective properties**, showing excellent performance in anti-myocardial fibrosis and reparative medicine.

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### 6. Summary Table of Physicochemical Characteristics

| ---- | ------------ |

| Molecular Weight|887.04 Da |

| Appearance|White to off-white lyophilized powder |

| pH Range|5.0–7.0 |

| Melting Point|Approximately 200℃ (decomposes) |

| Storage Conditions|Store at -20℃ in a dry, light-protected place |

| Detection Method|HPLC >=98% purity |

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### 7. Application Areas

1. **Biomedical Research**:

Widely used to study the regulation of growth hormone secretion, myocardial repair, and anti-aging mechanisms.

2. **Sports and Physical Fitness Research**:

Used under research conditions to explore the mechanisms of muscle synthesis, bone density improvement, and recovery speed.

3. **Drug Development:**

As a foundational molecule for novel GHS receptor agonists, it is used to develop candidate drugs for anti-aging, cardioprotection, and osteoporosis.

4. **Cellular and Molecular Biology Experiments:**

As a physiological stimulant, it is used to detect changes in the activity of GH-related signaling pathways.

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### 8. Summary

Hexarelin, as a high-purity and stable artificial hexapeptide, exhibits multiple biological activities in promoting growth hormone release, cardiovascular protection, and tissue repair. With its excellent physicochemical properties (such as high purity, good solubility, and structural stability), it is of great significance in scientific research and pharmaceutical development. With the deepening research into the GHS receptor mechanism, hexarelin and its derivatives are expected to become important molecular tools in the future fields of metabolic and regenerative medicine.